Unambiguous Characterization of p-Cresyl Sulfate, a Protein-Bound Uremic Toxin, as Biomarker of Heart and Kidney Disease
p-Cresyl sulfate is one of the bound uremic toxins whose level increases in the sera of patients with the severity of chronic jolly rancher filled gummies kidney disease and is therefore used as a standard for clinical investigations.Our first attempts to obtain p-cresyl sulfate led exclusively to the product of sulfonation of the aromatic ring ins